Diffusion, spread, and migration of botulinum toxin.
Identifieur interne : 000A26 ( Main/Exploration ); précédent : 000A25; suivant : 000A27Diffusion, spread, and migration of botulinum toxin.
Auteurs : Juan Ramirez-Castaneda [États-Unis] ; Joseph Jankovic [États-Unis] ; Cynthia Comella ; Khashayar Dashtipour ; Hubert H. Fernandez ; Zoltan MariSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2013.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Anti-Dyskinesia Agents, Botulinum Toxins.
- chemical , pharmacology : Anti-Dyskinesia Agents, Botulinum Toxins.
- chemical , therapeutic use : Anti-Dyskinesia Agents, Botulinum Toxins.
- Animals, Humans.
Abstract
Botulinum toxin (BoNT) is an acetylcholine release inhibitor and a neuromuscular blocking agent used for the treatment of a variety of neurologic and medical conditions. The efficacy and safety of BoNT depends on accurate selection and identification of intended targets but also may be determined by other factors, including physical spread of the molecule from the injection site, passive diffusion, and migration to distal sites via axonal or hematogenous transport. The passive kinetic dispersion of the toxin away from the injection site in a gradient-dependent manner may also play a role in toxin spread. In addition to unique properties of the various BoNT products, volume and dilution may also influence local and systemic distribution of BoNT. Most of the local and remote complications of BoNT injections are thought to be due to unwanted spread or diffusion of the toxin's biologic activity into adjacent and distal muscles. Despite widespread therapeutic and cosmetic use of BoNT over more than three decades, there is a remarkable paucity of published data on the mechanisms of distribution and its effects on clinical outcomes. The primary aim of this article is to critically review the available experimental and clinical literature and place it in the practical context.
DOI: 10.1002/mds.25582
PubMed: 23868503
Affiliations:
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Fernandez</name></author><author><name sortKey="Mari, Zoltan" sort="Mari, Zoltan" uniqKey="Mari Z" first="Zoltan" last="Mari">Zoltan Mari</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23868503</idno><idno type="pmid">23868503</idno><idno type="doi">10.1002/mds.25582</idno><idno type="wicri:Area/PubMed/Corpus">000821</idno><idno type="wicri:Area/PubMed/Curation">000821</idno><idno type="wicri:Area/PubMed/Checkpoint">000A35</idno><idno type="wicri:Area/Ncbi/Merge">003C61</idno><idno type="wicri:Area/Ncbi/Curation">003C61</idno><idno type="wicri:Area/Ncbi/Checkpoint">003C61</idno><idno type="wicri:Area/Main/Merge">000A26</idno><idno type="wicri:Area/Main/Curation">000A26</idno><idno type="wicri:Area/Main/Exploration">000A26</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Diffusion, spread, and migration of botulinum toxin.</title><author><name sortKey="Ramirez Castaneda, Juan" sort="Ramirez Castaneda, Juan" uniqKey="Ramirez Castaneda J" first="Juan" last="Ramirez-Castaneda">Juan Ramirez-Castaneda</name><affiliation wicri:level="2"><nlm:affiliation>Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name><affiliation><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university" n="3">Baylor College of Medicine</orgName></affiliation></author><author><name sortKey="Comella, Cynthia" sort="Comella, Cynthia" uniqKey="Comella C" first="Cynthia" last="Comella">Cynthia Comella</name></author><author><name sortKey="Dashtipour, Khashayar" sort="Dashtipour, Khashayar" uniqKey="Dashtipour K" first="Khashayar" last="Dashtipour">Khashayar Dashtipour</name></author><author><name sortKey="Fernandez, Hubert H" sort="Fernandez, Hubert H" uniqKey="Fernandez H" first="Hubert H" last="Fernandez">Hubert H. Fernandez</name></author><author><name sortKey="Mari, Zoltan" sort="Mari, Zoltan" uniqKey="Mari Z" first="Zoltan" last="Mari">Zoltan Mari</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Anti-Dyskinesia Agents (metabolism)</term><term>Anti-Dyskinesia Agents (pharmacology)</term><term>Anti-Dyskinesia Agents (therapeutic use)</term><term>Botulinum Toxins (metabolism)</term><term>Botulinum Toxins (pharmacology)</term><term>Botulinum Toxins (therapeutic use)</term><term>Humans</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Anti-Dyskinesia Agents</term><term>Botulinum Toxins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Dyskinesia Agents</term><term>Botulinum Toxins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-Dyskinesia Agents</term><term>Botulinum Toxins</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Botulinum toxin (BoNT) is an acetylcholine release inhibitor and a neuromuscular blocking agent used for the treatment of a variety of neurologic and medical conditions. The efficacy and safety of BoNT depends on accurate selection and identification of intended targets but also may be determined by other factors, including physical spread of the molecule from the injection site, passive diffusion, and migration to distal sites via axonal or hematogenous transport. The passive kinetic dispersion of the toxin away from the injection site in a gradient-dependent manner may also play a role in toxin spread. In addition to unique properties of the various BoNT products, volume and dilution may also influence local and systemic distribution of BoNT. Most of the local and remote complications of BoNT injections are thought to be due to unwanted spread or diffusion of the toxin's biologic activity into adjacent and distal muscles. Despite widespread therapeutic and cosmetic use of BoNT over more than three decades, there is a remarkable paucity of published data on the mechanisms of distribution and its effects on clinical outcomes. The primary aim of this article is to critically review the available experimental and clinical literature and place it in the practical context.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Texas</li></region><settlement><li>Houston</li></settlement><orgName><li>Baylor College of Medicine</li></orgName></list><tree><noCountry><name sortKey="Comella, Cynthia" sort="Comella, Cynthia" uniqKey="Comella C" first="Cynthia" last="Comella">Cynthia Comella</name><name sortKey="Dashtipour, Khashayar" sort="Dashtipour, Khashayar" uniqKey="Dashtipour K" first="Khashayar" last="Dashtipour">Khashayar Dashtipour</name><name sortKey="Fernandez, Hubert H" sort="Fernandez, Hubert H" uniqKey="Fernandez H" first="Hubert H" last="Fernandez">Hubert H. Fernandez</name><name sortKey="Mari, Zoltan" sort="Mari, Zoltan" uniqKey="Mari Z" first="Zoltan" last="Mari">Zoltan Mari</name></noCountry><country name="États-Unis"><region name="Texas"><name sortKey="Ramirez Castaneda, Juan" sort="Ramirez Castaneda, Juan" uniqKey="Ramirez Castaneda J" first="Juan" last="Ramirez-Castaneda">Juan Ramirez-Castaneda</name></region><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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